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Updated: Jul 9, 2026

Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds
Published on: October 15, 2019
2,6,7-trithiabicyclo[2.2.2]octanes as promising photolabile tags for combinatorial encoding
Roman A Valiulin1, Andrei G Kutateladze
1Department of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80208, USA.
Abstract:
The adducts of trithiabicyclo[2.2.2]octane (TTBO) and carbonyl compounds undergo efficient photoinduced fragmentation with quantum yields comparable to that of dithiane adducts. The effect of the third sulfur on the stability of the respective radical cations and radicals is examined computationally and experimentally in a laser flash photolysis study. A straightforward synthetic approach to a variety of 4-substituted trithiabicyclo[2.2.2]octanes from 3-bromo-2,2-bis(bromomethyl)propanol is developed, making a diverse set of mass-differentiated photolabile tags readily available for combinatorial encoding.
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