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Related Experiment Videos

MRSA in Austria--an overview.

K Krziwanek1, C Luger, B Sammer

  • 1National Reference Centre for Nosocomial Infections and Antibiotic Resistance, Department of Hygiene, Microbiology and Tropical Medicine, Elisabethinen Hospital Linz, Linz, Austria. karina.krziwanek@elisabethinen.or.at

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
|December 12, 2007
PubMed
Summary
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This study tracked methicillin-resistant Staphylococcus aureus (MRSA) strains in Austria from 1996-2006. The predominant MRSA clones identified were ST228 and ST5, with regional variations observed across Austria.

Area of Science:

  • Microbiology
  • Epidemiology
  • Molecular Biology

Background:

  • Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant public health threat globally.
  • Understanding the genetic diversity and prevalence of MRSA strains is crucial for effective infection control.
  • Previous studies have highlighted the emergence and spread of various MRSA clones across Europe.

Purpose of the Study:

  • To provide a comprehensive overview of predominant and sporadic MRSA strains in major Austrian regions.
  • To compare Austrian MRSA strain profiles with those identified in other European countries.
  • To analyze trends in MRSA clone frequencies over a ten-year period.

Main Methods:

  • Analysis of 1439 MRSA isolates collected between 1996 and 2006 from five Austrian provinces.

Related Experiment Videos

  • Confirmation of MRSA using mecA/femA multiplex PCR assays.
  • Detection of Panton-Valentine leukocidin (PVL) genes by PCR.
  • Subtyping via SmaI macrorestriction digestion, pulsed-field gel electrophoresis (PFGE), cluster analysis, spa typing, and multilocus sequence typing (MLST).

    • Main Results:

    • Predominant MRSA clones in Austria included ST228 (southern German epidemic clone), ST5 (Rhine-Hessen MRSA), and the ST8 Austrian clone.
    • An increasing frequency of ST5 and ST228 lineages was observed.
    • PFGE analysis identified 20 distinct MRSA types and 321 subtypes, with significant regional variations in strain prevalence.
    • The MRSA strain landscape in Austria showed the greatest similarity to that of Germany.

    Conclusions:

    • The study identified key MRSA clones circulating in Austria, with ST228 and ST5 being the most prevalent.
    • Observed increases in ST5 and ST228 suggest evolving epidemiological trends.
    • Regional variations in MRSA prevalence underscore the need for localized surveillance and control strategies.
    • The genetic relatedness of Austrian MRSA strains to those in Germany provides insights into cross-border transmission patterns.