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When adaptive processes go awry: gain-of-function in SCN9A

F B J Young1

  • 1Centre for Molecular Medicine and Therapeutics, 950 West 28th Avenue, Vancouver, BC V5Z 4H4, Canada. fyoung@cmmt.ubc.ca

Clinical Genetics
|December 12, 2007
PubMed
Summary

No abstract available in PubMed .

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Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
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The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...