Age-dependent normative values for differential luminance sensitivity in automated static perimetry using the Octopus...

Area of Science:

• Ophthalmology
• Visual Science
• Medical Technology

Background:

• Accurate normative data is crucial for interpreting visual field (VF) test results.
• Existing models may not fully capture the age-dependency and asymmetry of the visual hill of vision.
• The Octopus 101 is a static automated perimetry instrument used for VF testing.

Purpose of the Study:

• To establish age-dependent normative differential luminance sensitivity (DLS) values for the Octopus 101.
• To develop a mathematical model characterizing age-dependency and asymmetry in the hill of vision.
• To provide a tool for predicting normal threshold values across different ages and locations.

Main Methods:

• Static automated perimetry was performed on 81 healthy subjects aged 10-79 years within the central 30 degrees VF.
• A 4-2-2 staircase strategy was employed with a 68-point test grid.
• Thresholds of DLS were estimated using the maximum likelihood method and fitted to a smooth mathematical model.

Main Results:

• The mathematical model demonstrated a satisfactory fit (r(2) = 0.74) to the normative data.
• Average DLS thresholds showed a quadratic relationship with age, remaining stable until age 40 and declining thereafter.
• Age-related decline in DLS increased with eccentricity, with a significant drop observed in the superior peripheral hemifield.

Conclusions:

• A new smooth mathematical model accurately predicts age-related normal threshold values within the 30-degree VF.
• This model facilitates the calculation of global and local defect measures, such as mean defects and p-values.
• The findings enhance the interpretation of visual field tests by accounting for age-related changes in visual sensitivity.