The incidence of cyclic vomiting syndrome in children: population-based study
Emer Fitzpatrick1, Billy Bourke, Brendan Drumm
1UCD School of Medicine and Medical Science, The Children's Research Centre, Our Lady's Children's Hospital, Crumlin, Dublin, Ireland.
Insights
Cyclic vomiting syndrome (CVS) affects children, with an incidence of 3.15 per 100,000 annually in Ireland. This condition often begins in early childhood, causing significant illness and missed school days.
Area of Science:
- Pediatric Gastroenterology
- Epidemiology
- Public Health
Background:
- Cyclic vomiting syndrome (CVS) is a disorder characterized by recurrent, severe vomiting episodes in children.
- Population-based incidence data for pediatric CVS has been lacking.
- Understanding CVS incidence and clinical features is crucial for diagnosis and management.
Purpose of the Study:
- To determine the population-based incidence of cyclic vomiting syndrome (CVS) in children in Ireland.
- To describe the clinical characteristics of pediatric CVS at the time of diagnosis.
Main Methods:
- A nationwide survey of all pediatricians in Ireland was conducted over one year (2005).
- The Irish Pediatric Surveillance Unit (IPSU) collected monthly reports of incident CVS cases based on established criteria.
- Demographic and clinical data were anonymously gathered from reporting physicians.
Main Results:
- The incidence of CVS in Ireland was determined to be 3.15 per 100,000 children annually.
- The median age at onset was 4 years, with 46% of cases starting by age 3.
- Affected children experienced a median of 8 episodes per year, with 85% missing school and 44% requiring hospitalization.
Conclusions:
- Pediatric cyclic vomiting syndrome (CVS) is a relatively common condition, with an incidence comparable to other childhood gastrointestinal diseases.
- CVS typically begins in early childhood and leads to significant morbidity.
- Early diagnosis and management are essential for affected children.
Objective:
Cyclic vomiting syndrome (CVS) is characterized by severe recurrent episodes of vomiting in an otherwise healthy child. Currently, there is no population data on the incidence of CVS. The aim of this study was to determine the incidence of CVS and to define the clinical characteristics of the condition at diagnosis.
Methods:
Each pediatrician on the island of Ireland was surveyed on a monthly basis from January 1, 2005 to December 31, 2005 by the Irish Pediatric Surveillance Unit (IPSU) and was asked to report any incident cases of CVS according to the criteria outlined by the First International Symposium on CVS. Subsequently, data on demographics and clinical features were collected anonymously from the reporting pediatricians.
Results:
Eighty-nine percent (1,647 of 1,848) of the surveillance cards were returned, reporting 41 valid cases of CVS. The incidence of CVS in Ireland was 3.15/100,000 children per annum for 2005 (95% confidence interval [CI] 2.19-4.11). The median age at diagnosis of CVS was 7.42 yr (range 1.8-15 yr). The median age at onset of CVS was 4 yr (range 0.5-14 yr) with 46% (19 of 41) of children having an onset at or before the age of 3 yr. The median number of episodes of CVS per child per year was eight (range 3-52); the median duration of an episode was 24 h (range 1 h to 5 days). Of school-age children, 85% (22 of 26) had missed school in the previous year due to CVS and 44% (18 of 41) were admitted to hospital for supportive treatment or investigation of CVS.
Conclusion:
CVS is a relatively common condition in pediatric patients, with an incidence comparable to other major gastrointestinal diseases of childhood, such as Crohn's disease. The onset of pediatric CVS is generally early in childhood and this disease causes significant morbidity in the majority of those affected.
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