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An Assay for Measuring the Effects of Ethanol on the Locomotion Speed of Caenorhabditis elegans
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GABAA alpha 4 receptor subunits and ethanol: a knockout punch?

John J Woodward1

  • 1Department of Neurosciences and Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, South Carolina 29425, USA. woodward@musc.edu

Alcoholism, Clinical and Experimental Research
|December 12, 2007
PubMed
Summary

No abstract available in PubMed .

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Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...

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