Related Experiment Video
Updated: Jul 9, 2026

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator
Published on: May 9, 2014
Biologically effective dose using reciprocal repair for varying fraction doses and fraction intervals
1Regional Medical Physics Department, Newcastle General Hospital, Newcastle upon Tyne, UK. andy.buckle@orh.nhs.uk
Abstract:
Hyperfractionated regimes are being used more frequently; this has created a clinical need for more sophisticated biologically effective dose (BED) calculations. A formula is given for calculating BED assuming reciprocal repair in the case of changing dose per fraction and changing interfraction interval. Example applications are given for hyperfractionated schedules. It is shown that the formula is useful for calculating isoeffective schedules for a treatment with unplanned gaps and for comparing regimes in trial design. This work should be of value for comparing risk across accelerated schedules when an organ of the central nervous system is at risk. Uncertainties in choice of parameter and model are discussed: the bi-exponential model of repair is invoked for this purpose.
More Related Videos
06:20Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
Published on: March 11, 2021
05:01Assessment of DNA Double Strand Break Repair Activity Using High-throughput and Quantitative Luminescence-Based Reporter Assays
Published on: June 14, 2024
Related Concept Videos
Long-patch Base Excision Repair
Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Drug Accumulation During Multiple Dosing: Repetitive IV Injections
Biological Effects of Radiation
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses
Dosage Regimen: Fixed Dose
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...