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Updated: Jul 9, 2026

A Method for Murine Islet Isolation and Subcapsular Kidney Transplantation
Published on: April 13, 2011
Metabolic and immunological features of the failing islet-transplanted patient
Paolo Fiorina1, Andrea Vergani, Alessandra Petrelli
1Department of Medicine, San Raffaele Scientific Institute, Milan, Italy.
Objective:
This retrospective study was designed to identify metabolic and immune predictors of early islet allograft failure.
Research Design And Methods:
We measured several metabolic and immunological markers at the time of pretransplant and several time points posttransplantation in 17 patients with long-term functioning graft (long fx) and 20 patients with short-term functioning graft (short fx).
Results:
The short fx group showed higher insulin resistance, altered proinsulin processing, lower soluble interleukin-2 receptor (sIL-2r) (marker of T-cell activation), and higher soluble FasL (marker of apoptosis) during the entire follow-up, particularly at time of failure.
Conclusions:
Patients who experienced an early failure of islet allograft showed specific metabolic and immunological signs long before islet failure.
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