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Nephrogenic systemic fibrosis.

Diego R Martin1

  • 1Department of Radiology, Emory University Hospital, Building A, AT622 1365 Clifton Road, NE, Atlanta, GA 30322, USA. Diego_Martin@emoryhealthcare.org

Pediatric Radiology
|December 12, 2007
PubMed
Summary
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Nephrogenic systemic fibrosis (NSF) risk increases with higher doses of gadolinium-based contrast agents (GBCA). Specific GBCA formulations, like gadodiamide, show a higher associated risk in patients with severe kidney insufficiency.

Area of Science:

  • Nephrology
  • Dermatology
  • Radiology

Background:

  • Nephrogenic systemic fibrosis (NSF) is a serious fibrotic condition.
  • NSF is linked to severe renal insufficiency and gadolinium-based contrast agent (GBCA) administration.
  • The disease can present with joint contractures and may be fatal.

Purpose of the Study:

  • To review evidence on Nephrogenic systemic fibrosis (NSF).
  • To analyze the association between GBCA administration and NSF.
  • To provide recommendations for GBCA use in MRI.

Main Methods:

  • Retrospective study at the authors' center.
  • Review of general clinical experience with GBCA.
  • Analysis of GBCA dose and formulation in relation to NSF incidence.

Related Experiment Videos

Main Results:

  • NSF risk is associated with higher GBCA doses.
  • Different gadolinium-chelate formulations present varying risks.
  • Gadodiamide (Omniscan) showed the highest relative risk for NSF.

Conclusions:

  • GBCA administration requires careful consideration in patients with renal insufficiency.
  • Higher GBCA doses increase the risk of NSF.
  • Formulation of the GBCA is a critical factor in NSF risk assessment.