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Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

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Published on: January 17, 2018

Empty sella syndrome associated with a hyperfunctioning microadenoma invading the clivus.

C J Coulson¹, M A Siddiq, A P Johnson

¹Department of Otolaryngology, Head and Neck Surgery, Queen Elizabeth Hospital, Birmingham, UK. chriscoulson@doctors.org.uk

British Journal of Neurosurgery

|December 12, 2007

Summary

Empty sella syndrome typically involves normal pituitary function, but this study reports the first cases of microadenomas invading the clivus alongside empty sella.

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Area of Science:

Neuroendocrinology
Neurosurgery
Radiology

Background:

Empty sella syndrome (ESS) is a condition where the pituitary gland appears flattened within the sella turcica.
Pituitary function is usually preserved in ESS, with hypofunction being the most common dysfunction.
Hyperfunctioning pituitary microadenomas have been previously reported in association with ESS.

Observation:

This study presents novel cases of pituitary microadenomas.
These microadenomas were observed to invade the clivus.
The cases occurred in patients with coexisting empty sella syndrome.

Findings:

The primary finding is the first documented instance of a pituitary microadenoma invading the clivus in the context of empty sella syndrome.
This challenges the typical understanding of pituitary gland behavior within an empty sella.
The specific characteristics and behavior of these invading microadenomas are detailed.

Implications:

These findings expand the spectrum of potential complications associated with empty sella syndrome.
Understanding clival invasion by microadenomas in ESS is crucial for accurate diagnosis and surgical planning.
Further research is warranted to elucidate the mechanisms and clinical significance of this rare association.