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Updated: Jul 9, 2026
08:24
Measuring Bone Remodeling and Recreating the Tumor-Bone Microenvironment Using Calvaria Co-culture and Histomorphometry
Published on: March 14, 2020
Double aggressive osteoblastomas of calvarium.
Jiann-Her Lin1, En-Yuan Lin, Ming-Ying Liu
1Department of Neurological Surgery, Tri-service General Hospital, Taipei, Taiwan.
British Journal of Neurosurgery
|December 12, 2007
Summary
This study reports the first known case of double independent osteoblastomas in a patient
Area of Science:
- Neurosurgery
- Orthopedic Oncology
- Pathology
Background:
- Osteoblastomas are rare, benign bone tumors.
- They typically present as a single lesion.
Observation:
- A 55-year-old female presented with a painful right parietal skull mass.
- Imaging revealed a second, smaller lesion in the right frontal skull.
- Both lesions were surgically excised.
Findings:
- Pathological examination confirmed both lesions as aggressive osteoblastomas.
- This is the first reported instance of double independent osteoblastomas in the skull.
- A whole-body bone scan excluded other osteoblastoma foci.
Implications:
- This case highlights the possibility of multiple osteoblastomas.
- It underscores the importance of thorough imaging and pathological evaluation.
- Surgical strategies for managing multiple cranial osteoblastomas are discussed.
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