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Related Concept Videos

Jaundice01:25

Jaundice

Jaundice, or icterus, is the yellow discoloration of the skin, sclerae, and mucous membranes. It happens when plasma bilirubin levels rise above 2.5-3 mg/dL, leading to bilirubin deposition in tissue.Bilirubin is a byproduct of hemoglobin degradation. In macrophages, hemoglobin breaks down into globin and heme. Globin is converted into amino acids, while heme is turned into biliverdin by heme oxygenase, which is then reduced to unconjugated bilirubin by biliverdin reductase.Unconjugated...
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The gastric mucosa produces prostaglandins E2 (PGE2) and prostacyclin (PGI2), crucial in maintaining gastric health. They exert cytoprotective effects, including increasing bicarbonate secretion, releasing protective mucin, reducing gastric acid output, and preventing harmful vasoconstriction. These effects are mediated through various receptors, such as EP1, EP2, EP3, and EP4.
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Creation of Reversible Cholestatic Rat Model
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Published on: May 21, 2011

Intestinal prostaglandin E2 expression in rats with obstructive jaundice.

A Aslan1, M Bulbul, O Elpek

  • 1Department of Pediatric Surgery, Akdeniz University School of Medicine, Antalya, Turkey. adaslan@yahoo.com

European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [Et Al] = Zeitschrift Fur Kinderchirurgie
|December 12, 2007
PubMed
Summary

Obstructive jaundice in rats significantly reduces intestinal prostaglandin E2 (PGE2) levels, a key protective factor. This reduction correlates with increased intestinal injury and precirrhotic changes, highlighting a compromised cytoprotective process.

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Area of Science:

  • Gastroenterology
  • Hepatology
  • Surgical Pathology

Background:

  • Obstructive jaundice is linked to intestinal barrier dysfunction, but the underlying mechanisms remain unclear.
  • Intestinal prostaglandin E2 (PGE2) is a known cytoprotective factor with a potential role in maintaining intestinal integrity.

Purpose of the Study:

  • To investigate the effect of obstructive jaundice on intestinal prostaglandin E2 (PGE2) levels in a rat model.
  • To correlate changes in PGE2 levels with histopathological evidence of intestinal injury and fibrosis.

Main Methods:

  • Wistar-Albino rats underwent common bile duct ligation or sham operations.
  • Intestinal tissues (jejunum, ileum) and liver were collected at one and two weeks post-operation.
  • Analysis included intestinal PGE2 quantification and histopathological evaluation using Chiu scores.

Main Results:

  • Bile duct ligation significantly reduced jejunal and ileal PGE2 levels, particularly at two weeks.
  • Intestinal injury scores (Chiu) were elevated in ligated rats compared to controls, worsening over time.
  • Precirrhotic liver fibrosis was observed in rats with two-week bile duct obstruction.

Conclusions:

  • Obstructive jaundice leads to decreased intestinal PGE2 levels, suggesting impaired cytoprotection.
  • The observed reduction in PGE2 is associated with significant intestinal tissue injury and precirrhotic changes.
  • These findings implicate reduced PGE2 as a contributing factor to intestinal damage in obstructive jaundice.