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Reversible cardiomyopathy complicating intrathecal baclofen withdrawal: a case report
Anthony F Pizon1, Frank Lovecchio
1University of Pittsburgh School of Medicine, Division of Medical Toxicology, Pittsburgh, PA, USA. pizonaf@upmc.edu
Abstract:
This case report is about reversible cardiomyopathy associated with intrathecal baclofen withdrawal. Previous literature has reported that enteral baclofen does not adequately control intrathecal baclofen withdrawal. In our case, coronary atherosclerosis did not play a role in the development of the cardiomyopathy. However, reinstitution of intrathecal baclofen promptly resulted in improvement. One could hypothesize that myocardial stunning from sympathetic hyperactivity led to a similar cardiomyopathy reported with catecholamine excess or acute sympathomimetic poisoning.
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