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Updated: Jul 9, 2026

A Non-random Mouse Model for Pharmacological Reactivation of Mecp2 on the Inactive X Chromosome
Published on: May 22, 2019
Building up the inactive X chromosome
Maria R Matarazzo1, Andrea Cerase, Maurizio D'Esposito
1Institute of Genetics and Biophysics A. Buzzati Traverso, National Research Council (CNR), via Castellino 111, Naples, Italy.
Abstract:
The compensation of the different level of transcripts of X-linked genes in male and female mammals is achieved through X chromosome inactivation, a complex process that differentially regulates the sex chromosomes of female cells. This mechanism has been dissected at evolutionary, genetic and molecular levels: here, we discuss some of the latest examples that illustrate better these intricate connections, focusing particularly on the emerging role of spatial and three-dimensional chromatin arrangements in the building of this special chromosome, the inactive X chromosome.
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