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Related Experiment Videos

The telomerase database.

Joshua D Podlevsky1, Christopher J Bley, Rebecca V Omana

  • 1School of Life Sciences and Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287, USA.

Nucleic Acids Research
|December 13, 2007
PubMed
Summary
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The Telomerase Database consolidates extensive data on telomerase, an enzyme crucial for DNA maintenance and cellular immortality. This resource aids researchers investigating telomerase structure, function, evolution, and medical significance.

Area of Science:

  • Molecular Biology
  • Biochemistry
  • Genetics

Background:

  • Telomerase is a key enzyme in eukaryotes, responsible for DNA extension at chromosome ends.
  • Its roles in chromosome stability and cellular immortality have driven significant research interest.
  • Over 160 eukaryotic species' telomerase components have been identified.

Purpose of the Study:

  • To create a comprehensive database of telomerase information.
  • To organize and present diverse data for easier researcher access.
  • To support research into telomerase structure, function, evolution, and medical relevance.

Main Methods:

  • Compilation of existing telomerase-related data.
  • Development of the Telomerase Database (http://telomerase.asu.edu/).

Related Experiment Videos

  • Hierarchical organization of information by telomerase components (TERT, TR, associated proteins).

    • Main Results:

    • The Telomerase Database now offers extensive information on telomerase.
    • Includes sequences, alignments, structures (RNA secondary, protein tertiary), mutations, and researchers.
    • Data is organized by telomerase reverse transcriptase (TERT), telomerase RNA (TR), and other proteins.

    Conclusions:

    • The Telomerase Database serves as a valuable resource for the scientific community.
    • Facilitates in-depth investigation of telomerase enzyme properties.
    • Supports research on the medical implications of telomerase.