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Utah family-based analysis: past, present and future.

Lisa A Cannon Albright¹

¹Division of Genetic Epidemiology, Department of Biomedical Informatics, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA. lisa.albright@utah.edu

|December 13, 2007

Summary

A unique Utah genealogical and phenotype dataset, established over 30 years ago, aids in understanding genetic contributions to diseases. Current methods analyze this resource to identify predisposition genes.

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Area of Science:

Genetics and Genealogy
Population Health Research

Background:

A comprehensive genealogical resource linked with phenotype data was established in Utah over three decades ago.
This resource provides a unique foundation for genetic and epidemiological studies.

Observation:

The resource's history and extensive content are detailed.
It facilitates the study of heritability and genetic predispositions.

Findings:

Three methodologies are reviewed for analyzing the resource to determine the heritable contribution to phenotypes.
These methods aim to identify specific genes linked to disease predisposition.
Illustrative analyses and high-risk family pedigrees are presented.

Implications:

The findings highlight the utility of integrated genealogical and phenotype data for genetic research.
Future expansion of this resource and similar datasets could enhance our understanding of complex diseases.
This work underscores the value of long-term data collection for genetic discovery.