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Geometric triangular chiral hexagon crystal-like complexes organization in pathological tissues biological collision
Jairo A Díaz1, Natalia A Jaramillo, Mauricio F Murillo
1Laboratory of Pathology, Department of Pathology, Clinic Health Social Entity Policarpa Salavarrieta, University Cooperativa of Colombia, Medicine School, Villavicencio, Meta, Colombia. jaditod@hotmail.com
Plos One
|December 13, 2007
Summary
Researchers discovered self-assembling geometric triangular chiral hexagon crystal-like complex organizations (GTCHC) in human pathological tissues, particularly in cancer. These structures arise from electromagnetic interactions within the extracellular matrix, suggesting new therapeutic avenues.
Area of Science:
- Biophysics
- Materials Science
- Pathology
Background:
- Self-assembly of complex organizations in biological systems is not fully understood.
- Geometric and chiral structures have been observed in pathological tissues.
- The role of extracellular matrix components in tissue architecture is crucial.
Purpose of the Study:
- To describe and document self-assembly of geometric triangular chiral hexagon crystal-like complex organizations (GTCHC) in human pathological tissues.
- To investigate the genesis mechanism of these GTCHC structures.
- To explore potential therapeutic applications of these findings in cancer.
Main Methods:
- Macroscopic and histopathologic analyses of 3000 surgical specimens (2600 inflammatory, 400 malignant).
- Development of an experimental model simulating electromagnetic collisions on helicoidal conductance patterns.
- Analysis of extracellular matrix constituents and piezoelectric activity.
Main Results:
- GTCHC were identified at macroscopic and microscopic levels, predominantly in cancer.
- An experimental model successfully reproduced polarity, chirality, helicoid geometry, and triangular/hexagonal clusters via electromagnetic collisions.
- Piezoelectric activity from extracellular matrix interactions is implicated in GTCHC genesis.
Conclusions:
- GTCHC, molecular crystals of triangular chiral hexagons, emerge from collision-attraction events with collagen type I fibrils.
- These structures represent energy flow and chiral electromagnetic interactions in pathological tissues.
- GTCHC may represent a geometry of equilibrium in perturbed biological systems, offering potential for novel cancer therapies.
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