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Updated: Jul 9, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Tumor necrosis factor alpha is not a pathogenic determinant in acute lethal encephalitis induced by a highly
Kazuya Shirato1, Eiichi Momotani, Masuhiro Takata
1Laboratory of Veterinary Microbiology, Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, 183-8509, Japan.
Abstract:
To investigate the role of tumor necrosis factor alpha (TNFalpha) in the pathogenesis of acute viral encephalitis, TNFalpha-deficient mice were infected with a highly neurovirulent strain of mouse hepatitis virus, JHM, and compared with JHM-infected C57BL/6 mice as controls. All the JHM-infected mice had succumbed to infection by 6 days postinfection. The virus replication kinetics, histopathological changes and mRNA expression levels of proinflammatory cytokines in the brain did not differ between TNFalpha-deficient and control C57BL/6 mice. These results suggest that TNFalpha is not a pathogenic determinant in JHM-induced acute lethal encephalitis.
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