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Formation of Muscle Fibers from Myoblasts

Formation of Muscle Fibers from Myoblasts

De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription factors...

Fibril-associated Collagen

Fibril-associated Collagen

Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...

Types of Intermediate Filaments

Types of Intermediate Filaments

The intermediate filaments are an essential component of the cytoskeleton. Presently six types of intermediate filament have been identified. Type I and II are acidic and basic keratin proteins. Type III is of mesodermal origin and comprises four proteins: vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Vimentin is commonly found in mesenchymal cells, desmin in muscle cells, GFAP in astrocytes, while peripherin is found in peripheral nervous system neurons (PNS). Type...

Classification of Skeletal Muscle Fibers

Classification of Skeletal Muscle Fibers

Skeletal muscles continuously produce ATP to provide the energy that enables muscle contractions. Skeletal muscle fibers can be categorized into three types based on differences in their contraction speed and how they produce ATP, as well as physical differences related to these factors. Most human muscles contain all three muscle fiber types, albeit in varying proportions.
Slow-Twitch Muscle Fibers
Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...

Disorders of the Skeletal Muscle

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...

Satellite Stem Cells and Muscular Dystrophy

Satellite Stem Cells and Muscular Dystrophy

Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...

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Related Experiment Video

Updated: Jul 9, 2026

Direct Reprogramming of Human Fibroblasts into Myoblasts to Investigate Therapies for Neuromuscular Disorders

Direct Reprogramming of Human Fibroblasts into Myoblasts to Investigate Therapies for Neuromuscular Disorders

Published on: April 3, 2021

Infantile myofibromatosis.

Milan Gopal¹, Gurdip Chahal, Ziad Al-Rifai

¹Department of Paediatric Surgery, University Hospitals of Leicester NHS Trust, Leicester, UK. milanmail@yahoo.com

Pediatric Surgery International

|December 13, 2007

Summary

Infantile myofibromatosis, a rare fibrous tumor in infants, presents diagnostic challenges. This study reviews 12 cases, highlighting diverse presentations like retroperitoneal masses and scrotal masses.

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Published on: October 12, 2013

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Direct Reprogramming of Human Fibroblasts into Myoblasts to Investigate Therapies for Neuromuscular Disorders

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Published on: April 3, 2021

Isolation of Primary Myofibroblasts from Mouse and Human Colon Tissue

Isolation of Primary Myofibroblasts from Mouse and Human Colon Tissue

Published on: October 12, 2013

Area of Science:

Pediatric Oncology
Dermatopathology
Surgical Pathology

Background:

Infantile myofibromatosis is the most common fibrous tumor in infants.
Despite its prevalence, it remains a rare condition, often leading to diagnostic uncertainty among clinicians.

Observation:

The study analyzed 12 cases of infantile myofibromatosis over 14 years.
Three distinct cases were highlighted: a typical presentation, a retroperitoneal myofibroma causing duodenal obstruction, and an isolated scrotal mass.

Findings:

Case presentations demonstrate the varied clinical manifestations of infantile myofibromatosis.
The retroperitoneal case underscores potential for significant internal complications.
The scrotal mass case illustrates unusual localized presentations.

Implications:

Increased awareness of infantile myofibromatosis and its diverse presentations is crucial for timely diagnosis.
Recognizing atypical sites and symptoms aids in differentiating from other pediatric tumors.
Further research into the pathogenesis and optimal management strategies is warranted.