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Related Concept Videos

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...

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Related Experiment Video

Updated: Jul 9, 2026

Sleeve Gastrectomy in Mice using Surgical Clips
05:16

Sleeve Gastrectomy in Mice using Surgical Clips

Published on: November 14, 2020

The decrease in serum IL-18 levels after bariatric surgery in morbidly obese women is a time-dependent event.

José I Botella-Carretero1, Francisco Alvarez-Blasco, M Angeles Martinez-García

  • 1Department of Endocrinology, Hospital Ramón y Cajal and Universidad de Alcalá, Madrid, Spain.

Obesity Surgery
|December 13, 2007
PubMed
Summary

Bariatric surgery significantly reduces interleukin-18 (IL-18), a marker of inflammation and cardiovascular risk. This reduction is time-dependent and linked to waist circumference changes, not just weight loss.

Related Experiment Videos

Last Updated: Jul 9, 2026

Sleeve Gastrectomy in Mice using Surgical Clips
05:16

Sleeve Gastrectomy in Mice using Surgical Clips

Published on: November 14, 2020

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Metabolic Surgery

Background:

  • Morbid obesity is associated with elevated levels of the proinflammatory serum marker interleukin-18 (IL-18), a risk factor for cardiovascular disease.
  • Bariatric surgery leads to significant weight loss, but its impact on IL-18 levels, considering reproductive status and time post-surgery, requires further evaluation.

Purpose of the Study:

  • To assess the effect of bariatric surgery on serum IL-18 levels in morbidly obese women.
  • To investigate the influence of reproductive status and time elapsed since surgery on IL-18 response to weight loss.

Main Methods:

  • Serum IL-18 was measured in 33 morbidly obese women pre-surgery and post-weight loss (≥15% initial weight).
  • Weight loss and waist circumference reduction were recorded, with follow-up ranging from 5 to 33 months.

Main Results:

  • A significant reduction in serum IL-18 was observed post-bariatric surgery (P<0.001).
  • The decrease in IL-18 was significantly correlated with the interaction between time since surgery and waist circumference reduction (R²=0.333, P<0.001).
  • Individual factors like time, weight loss percentage, menopausal status, or surgical type did not independently predict IL-18 reduction.

Conclusions:

  • Serum IL-18 levels decrease in a time-dependent manner after bariatric surgery, related to waist circumference reduction.
  • The inflammatory process amelioration requires time, not solely weight loss, potentially explaining early cardiovascular complications post-surgery.