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Related Experiment Video

Updated: Jul 9, 2026

Construction and Characterization of a Novel Vocal Fold Bioreactor

Construction and Characterization of a Novel Vocal Fold Bioreactor

Published on: August 1, 2014

Side population cells in the human vocal fold.

Masaru Yamashita¹, Shigeru Hirano, Shin-ichi Kanemaru

¹Division of Otolaryngology-Head and Neck Surgery, Dept of Surgery, University of Wisconsin-Madison, K4/723 Clinical Science Center, 600 Highland Ave, Madison, WI 53792, USA.

The Annals of Otology, Rhinology, and Laryngology

|December 14, 2007

Summary

This study found side population (SP) cells, which are stem cell-like, in the human vocal fold. These findings suggest a potential mechanism for vocal fold regeneration.

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Construction and Characterization of a Novel Vocal Fold Bioreactor

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Area of Science:

Regenerative Medicine
Stem Cell Biology
Otolaryngology

Background:

The regenerative capacity of vocal folds is poorly understood.
Stem cells are crucial for tissue repair and regeneration.
Side population (SP) cells, identified by their ability to exclude Hoechst 33342 dye, are enriched in stem cells.

Purpose of the Study:

To investigate the presence of SP cells in the human vocal fold.
To lay the groundwork for understanding vocal fold regenerative mechanisms.

Main Methods:

Human excised larynges were analyzed using fluorescence-activated cell sorting (FACS).
Immunohistochemical analysis was performed using antibodies against ABCG2, a marker for SP cells.

Main Results:

SP cells constituted approximately 0.2% of total cells in the human vocal fold.
ABCG2-positive cells were detected in both epithelial and subepithelial layers of the vocal fold.

Conclusions:

This study provides preliminary evidence for the existence of SP cells in the human vocal fold.
Further research is needed to elucidate the role of these SP cells in vocal fold regeneration.