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[The protective effects of tenuigenin on the PC12 cells injury induced by H2O2]
Gui-bo Sun1, Xiang-chao Deng, Chu-hua Li
1College of Life Science, South China Normal University, Guangzhou 510631, China. sunguibo@126.com
Objective:
To study the protective effects of tenuigenin (TEN) on the PC12 cells injury induced by H2O2.
Methods:
Oxidative damage PC12 cells model was induced by H2O2. The survival rate of the cells was determined by MTT method. The content of LDH was determined by ultraviolet spectrophometry and the content of MDA and SOD activity was measured respectively by thiobarbituric acid and xanthine oxidese method.
Results:
tenuigenin could reduce obviously cells injury induced by H2O2. 10 mg L(-1) tenuigenin could improve the cells survival rate, reduce LDH releasing and MDA content, increase SOD activity.
Conclusion:
tenuigenin have significantly potective effect on the PC12 cells injury induced by H2O2.
