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Related Experiment Video

Updated: Jul 9, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Which patients with sexual dysfunction are suitable for testosterone replacement therapy?

A Morelli¹, G Corona, S Filippi

¹Andrology Unit, Department of Clinical Physiopathology, University of Florence, 50139 Florence, Italy.

Journal of Endocrinological Investigation

|December 14, 2007

Summary

This summary is machine-generated.

Late onset hypogonadism (LOH), or testosterone deficiency syndrome (TDS), requires symptoms for diagnosis. Testosterone plays a key role in men's sexual function and treating erectile dysfunction (ED).

Related Experiment Videos

Last Updated: Jul 9, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Area of Science:

Endocrinology
Urology
Andrology

Background:

Hypogonadism, defined as late onset hypogonadism (LOH) or testosterone deficiency syndrome (TDS), is a medical condition requiring symptomatic presentation.
Sexual dysfunction (SD) is a prevalent symptom associated with LOH/TDS.

Purpose of the Study:

This review examines the role of testosterone (T) in male sexual function, focusing on erectile dysfunction (ED).
It covers the epidemiology, pathophysiology, diagnosis, and treatment efficacy of T in ED patients.

Main Methods:

Literature review of studies on hypogonadism, testosterone, and erectile dysfunction.
Analysis of the prevalence, symptoms, and treatment outcomes in hypogonadal men with ED.

Main Results:

Prevalence of hypogonadism in men with ED varies from 1.7% to 35%.
Hypogonadism in ED patients is linked to decreased sexual desire and nocturnal erections; its effect on sex-induced erections is less clear.
Testosterone influences both the formation and breakdown of cyclic guanosine monophosphate (cGMP), impacting erectile function and PDE5 inhibitor efficacy.

Conclusions:

Recognizing hypogonadism is crucial for effectively treating ED.
Testosterone substitution can restore responsiveness to PDE5 inhibitors in hypogonadal patients with ED.
Diagnostic tools like ANDROTEST may aid in identifying LOH/TDS in patients with SD.