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Prostaglandin E2: making more of your marrow

Allegra M Lord1, Trista E North, Leonard I Zon

  • 1Stem Cell Program and Hematology/Oncology, Children's Hospital and Dana- Farber Cancer Institute, HHMI, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

Cell Cycle (Georgetown, Tex.)
|December 14, 2007
PubMed
Summary

Prostaglandin E2 (PGE2) regulates hematopoietic stem cell (HSC) number across species. PGE2 may expand HSCs for improved transplantation outcomes after chemotherapy or irradiation.

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