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Survivin, cancer networks and pathway-directed drug discovery

Dario C Altieri1

  • 1Department of Cancer Biology and the Cancer Center, Lazare Research Building 428, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA. dario.altieri@umassmed.edu

Nature Reviews. Cancer
|December 14, 2007
PubMed

Insights

Survivin is a key molecule in cancer, regulating tumor cell growth and survival. Targeting survivin

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Therapeutics

Background:

  • Identifying novel cancer therapeutic targets is crucial.
  • Few molecules are differentially expressed in cancer and regulate multiple tumor maintenance pathways.

Purpose of the Study:

  • To highlight survivin as a significant molecular target in cancer.
  • To explore survivin's role in orchestrating cellular networks essential for tumor progression.

Main Methods:

  • Literature review and analysis of survivin's molecular functions.
  • Examination of survivin's involvement in cancer cell proliferation and viability.

Main Results:

  • Survivin is differentially expressed in cancer.
  • Survivin integrates multiple pathways vital for tumor maintenance.
  • Survivin is essential for tumor cell proliferation and viability.

Conclusions:

  • Survivin represents a promising target for cancer therapeutics.
  • Targeting survivin's nodal functions could lead to global pathway inhibitors.
  • This approach may offer unique therapeutic potential for cancer treatment.

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