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Updated: Jul 9, 2026
12:04
The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
PTPN22: its role in SLE and autoimmunity.
Sharon A Chung1, Lindsey A Criswell
1Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California, San Francisco, CA, USA.
Autoimmunity
|December 14, 2007
Summary
A specific variant of protein tyrosine phosphatase nonreceptor 22 (PTPN22) is linked to several autoimmune diseases. This review examines PTPN22
Area of Science:
- Immunogenetics
- Molecular Biology
- Autoimmunity
Background:
- The protein tyrosine phosphatase nonreceptor 22 (PTPN22) gene plays a crucial role in immune system regulation.
- A specific functional variant of PTPN22 has been implicated in the pathogenesis of various autoimmune conditions.
Purpose of the Study:
- To review the structure and function of the PTPN22 gene.
- To discuss PTPN22 polymorphisms associated with autoimmune diseases.
- To synthesize evidence linking PTPN22 to systemic lupus erythematosus (SLE) and other autoimmune disorders.
Main Methods:
- Literature review of genetic association studies.
- Analysis of PTPN22 gene structure and function.
- Synthesis of data on PTPN22 polymorphisms and disease associations.
Main Results:
- The PTPN22 gene variant is a significant risk factor for multiple autoimmune diseases.
- Evidence supports a strong association between PTPN22 and systemic lupus erythematosus (SLE).
- PTPN22 polymorphisms are implicated in rheumatoid arthritis, type 1 diabetes, and autoimmune thyroid disease.
Conclusions:
- The PTPN22 gene variant is a key player in the development of autoimmune diseases.
- Targeting PTPN22 may offer therapeutic strategies for conditions like SLE.
- Further research into PTPN22's role can elucidate autoimmune disease mechanisms.
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