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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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The pathophysiology of pneumonia involves the following steps:

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Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment
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Interleukin-17 in pulmonary host defense.

Shean J Aujla1, Patricia J Dubin, Jay K Kolls

  • 1Division of Pulmonology, Department of Pediatrics, Children's Hospital of Pittsburgh and the University of Pittsburgh, Pittsburgh, PA 15213, USA.

Experimental Lung Research
|December 14, 2007
PubMed
Summary

Th17 cells produce Interleukin-17A (IL-17A) and IL-17F, crucial for fighting bacteria. However, these T helper 17 cells can also cause disease in conditions like asthma and autoimmunity.

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Published on: September 26, 2013

Area of Science:

  • Immunology
  • Cell Biology
  • Microbiology

Background:

  • Th17 cells are a distinct T cell subset producing IL-17A and IL-17F.
  • These cytokines signal through the IL-17 receptor (IL-17R), impacting host defense.
  • IL-17 and IL-22 also regulate antimicrobial protein production in epithelial cells.

Purpose of the Study:

  • To summarize the role of Th17 cells and their effector molecules in host defense and immunopathology.
  • To highlight the critical signaling pathways involving IL-17R.
  • To underscore the dual role of Th17 cells in immunity and disease.

Main Methods:

  • Review of existing literature on Th17 cell differentiation and function.
  • Analysis of the molecular mechanisms of IL-17A, IL-17F, and IL-22 signaling.
  • Examination of the involvement of Th17 cells in various disease settings.

Main Results:

  • Th17 cells, regulated by RORgammat, produce IL-17A, IL-17F, and IL-22.
  • IL-17A and IL-17F signaling via IL-17R is essential for combating extracellular bacteria.
  • These cytokines influence neutrophil recruitment and granulopoiesis.
  • IL-17 and IL-22 contribute to epithelial antimicrobial defense.

Conclusions:

  • Th17 cells play a vital role in mucosal immunity against bacterial infections.
  • Dysregulated Th17 cell activity contributes to immunopathology in asthma, chronic infection, and autoimmunity.
  • Understanding Th17 cell function is critical for developing targeted therapies.