Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microcirculation and oxidative stress.

E Crimi1, L J Ignarro, C Napoli

  • 1Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. ecrimi@partners.org

Free Radical Research
|December 14, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ensuring safety requirement to home food and home restaurant: focus on a regional experience based on sector legislation, and future perspectives.

Annali di igiene : medicina preventiva e di comunita·2023
Same author

Inhibiting DNA methylation as a strategy to enhance adipose-derived stem cells differentiation: Focus on the role of Akt/mTOR and Wnt/β-catenin pathways on adipogenesis.

Frontiers in cell and developmental biology·2022
Same author

Implementation of a quality management system according to ISO 9001:2015 standards in an Angiology Unit: an Italian experience.

Annali di igiene : medicina preventiva e di comunita·2022
Same author

Hierarchical convolutional models for automatic pneu-monia diagnosis based on X-ray images: new strategies in public health.

Annali di igiene : medicina preventiva e di comunita·2021
Same author

Severe Acute Respiratory Infections (SARI) surveillance in over-65-years-old patients: the experience of a University hospital (seasons 2017-2018 and 2018-2019).

Annali di igiene : medicina preventiva e di comunita·2021
Same author

SARS-CoV-2 indoor contamination: considerations on anti-COVID-19 management of ventilation systems, and finishing materials in healthcare facilities.

Annali di igiene : medicina preventiva e di comunita·2020
Same journal

Correction.

Free radical research·2026
Same journal

Midpoint potential of the phenoxyl radical/phenol redox couple of phytocannabinoids as a diagnostic tool for analyzing their prooxidant action in the cell.

Free radical research·2026
Same journal

Photoprotective effects of <i>Caulerpa lentillifera</i> extract against UV-induced cellular damage via Nrf2 activation and MMP inhibition.

Free radical research·2026
Same journal

Procontractile influence of ROS, produced by NADPH oxidase, is greater during contraction induced by thromboxane A<sub>2</sub> than α<sub>1</sub>-adrenoceptor activation.

Free radical research·2026
Same journal

Edaravone attenuates acrylamide-induced nephrotoxicity by modulating the endoplasmic reticulum stress pathway in rats.

Free radical research·2026
Same journal

Acidic plasma-activated povidone-iodine induces copper-dependent oxidative death in oral squamous cell carcinoma cells.

Free radical research·2026
See all related articles

The endothelium, crucial for microcirculation, maintains homeostasis via shear stress. Oxidative stress causes endothelial dysfunction, highlighting microvascular inflammation as a therapeutic target.

Area of Science:

  • Cardiovascular Biology
  • Cellular Physiology

Background:

  • The microcirculation delivers oxygen and nutrients, with the endothelium playing a central role in maintaining local balance.
  • Endothelial homeostasis relies on constant shear stress; disruptions alter vasodilator and vasoconstrictor secretion.
  • Oxidative stress is a key factor in endothelial dysfunction, reducing nitric oxide (NO) bioavailability and promoting inflammation.

Purpose of the Study:

  • To investigate the role of oxidative stress and microvascular inflammation in endothelial dysfunction.
  • To explore the potential of targeting these mechanisms for novel therapeutic strategies.

Main Methods:

  • Analysis of endothelial function under varying shear stress conditions.
  • Assessment of oxidative stress markers and inflammatory mediators.

Related Experiment Videos

  • Investigation of intracellular signaling pathways affected by oxidative stress.

    • Main Results:

    • Perturbed shear stress disrupts endothelial homeostasis and alters vasoactive agent secretion.
    • Increased oxidative stress impairs NO bioavailability, exacerbates inflammation, and affects cellular processes.
    • Oxidative stress influences ion channels, signal transduction, cytoskeleton, and gene expression.

    Conclusions:

    • Targeting microvascular inflammation and oxidative stress presents a promising therapeutic avenue.
    • Reducing endothelial dysfunction could decrease morbidity and mortality in various diseases.