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Terpenoids and phenolics from Plectranthus strigosus, bioactivity screening
Cristina Gaspar-Marques1, M Fátima Simões, M Luísa Valdeira
1CECF, Faculdade de Farmácia da Universidade de Lisboa, 1649-003 Lisboa, Portugal.
Natural Product Research
|December 14, 2007
Summary
Researchers isolated novel terpenes and phenol esters from Plectranthus strigosus, discovering herpetic inhibitory and antioxidant properties. These findings expand the known chemical constituents and bioactivities within the Plectranthus genus.
Area of Science:
- Phytochemistry
- Natural Products Chemistry
- Pharmacognosy
Background:
- Plectranthus species are known sources of bioactive compounds.
- Previous research on Plectranthus has identified various secondary metabolites.
Purpose of the Study:
- To isolate and characterize chemical constituents from Plectranthus strigosus.
- To evaluate the bioactivity of the isolated compounds.
Main Methods:
- Phytochemical investigation involving isolation techniques.
- Structure elucidation using spectral data.
- Bioactivity screening for herpetic inhibition and antioxidant properties.
Main Results:
- Isolation of ten compounds, including terpenes and phenol esters, some new to the Plectranthus genus.
- Compounds 1 and 2 exhibited herpetic inhibitory properties.
- Phenolic compounds 5 and 8 demonstrated antioxidant activity.
Conclusions:
- Plectranthus strigosus is a rich source of diverse terpenes and phenol esters.
- The isolated compounds possess significant biological activities, including antiviral and antioxidant potential.
- This study contributes to understanding the chemical diversity and pharmacological value of Plectranthus species.