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Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance

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Published on: February 17, 2023

Relationship between leptin concentration and insulin resistance.

Z Maghbooli¹, A Hossein-Nezhad, M Rahmani

¹Endocrinology & Metabolism Research Center, 5th Floor, Doctor Shariati Hospital, Tehran, Iran.

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme

|December 14, 2007

Summary

Elevated leptin levels in pregnant women are linked to insulin resistance and an increased risk of developing gestational diabetes mellitus (GDM). Measuring leptin may help identify women at risk for GDM.

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Published on: January 7, 2018

Area of Science:

Endocrinology
Metabolic Disorders
Reproductive Health

Background:

Leptin is known to inhibit insulin secretion.
Understanding leptin's role in pregnancy is crucial for metabolic health.
Gestational diabetes mellitus (GDM) poses risks to both mother and child.

Purpose of the Study:

To investigate the association between plasma leptin concentrations and insulin resistance in pregnant women with GDM.
To determine if leptin levels can predict the development of GDM.

Main Methods:

A cross-sectional study involving 741 pregnant women.
Screening using an oral glucose challenge test (50 g).
Diagnosis of GDM based on impaired oral glucose tolerance test (100 g) using Carpenter and Coustan criteria.
Measurement of plasma insulin and leptin concentrations.

Main Results:

GDM developed in 7% of pregnancies.
Elevated leptin concentrations were positively associated with insulin levels, BMI, and HOMA index.
Leptin levels showed an independent direct correlation with GDM after adjusting for age and pre-pregnancy BMI.
Leptin levels ≥ 20 ng/ml showed predictive value for GDM development.

Conclusions:

Plasma leptin concentrations are associated with insulin resistance in GDM.
Leptin measurement, alongside other risk factors, can aid in identifying women at risk of developing GDM.
Leptin may serve as a potential biomarker for predicting GDM.