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Updated: Jul 9, 2026

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking
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A prospective study of delusional misidentification syndromes in Parkinson's disease with dementia

Javier Pagonabarraga1, Gisela Llebaria, Carmen García-Sánchez

  • 1Movement Disorders Unit, Neurology Department, Sant Pau Hospital, Autonomous University of Barcelona, CIBERNED Barcelona, Spain.

Movement Disorders : Official Journal of the Movement Disorder Society
|December 14, 2007
PubMed

Insights

Delusional misidentification syndromes (DMS) affect 16.7% of Parkinson's disease with dementia (PDD) patients, often alongside severe hallucinations. These symptoms appear linked to memory and language deficits, suggesting temporal cortex involvement.

Area of Science:

  • Neuropsychiatry
  • Neurology
  • Cognitive Science

Background:

  • Delusional misidentification syndromes (DMS) are neuropsychiatric disorders linked to familiarity disturbances.
  • DMS are common in dementia with Lewy bodies (DLB).
  • The occurrence of DMS in Parkinson's disease with dementia (PDD) remains understudied.

Purpose of the Study:

  • To determine the frequency and clinical characteristics of DMS in PDD patients.
  • To compare the neuropsychological profiles of PDD patients with and without DMS.

Main Methods:

  • Prospective study of 30 PDD patients from an outpatient setting.
  • Structured behavioral interview for DMS and hallucinations.
  • Neuropsychological battery assessing executive function, memory, language, and visuospatial abilities.

Main Results:

  • DMS were present in 16.7% of PDD patients.
  • DMS patients had more severe hallucinations and responded to neuroleptic drugs.
  • PDD patients with DMS showed greater memory and language deficits compared to those without DMS, with similar executive and visuospatial impairment.

Conclusions:

  • DMS is a notable neuropsychiatric feature in PDD.
  • Prominent memory and language deficits in PDD with DMS suggest a role for the temporal cortex.
  • Further research into the neurobiological underpinnings of DMS in PDD is warranted.

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