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Related Concept Videos

Ethical Issues01:27

Ethical Issues

Nurses are essential in patient care, upholding the ethical principles of their profession and effectively navigating ethical dilemmas. Neglecting ethical issues can lead to inadequate patient care, compromised therapeutic relationships, and moral distress among healthcare workers.
Ethical Concerns in Healthcare:
Ethical Dilemmas II01:30

Ethical Dilemmas II

Resolving an ethical dilemma in healthcare involves a systematic approach that considers every aspect of the issue, respecting both the patient's needs and values and the healthcare professional's ethical obligations. Here are potential steps to resolve an ethical dilemma:
Ethical Standards II01:23

Ethical Standards II

Ethical standards are the backbone of nursing practice, guiding nurses as they interact with patients, families, and colleagues. These standards are crucial for providing safe, empathetic care centered on the patient's needs.
Nurses are entrusted with upholding various ethical principles and standards. Nurses forge solid therapeutic relationships using trust, empathy, autonomy, confidentiality, and professional competence.
Confidentiality is crucial, embodying respect for individual privacy and...
Ethical Standards I01:25

Ethical Standards I

The American Nurses Association (ANA) created and implemented the first nationally accepted Code of Ethics for Nurses with Interpretive Statements. The Code of Ethics is a living document regularly updated by the ANA and establishes an ethical standard that is non-negotiable for nurses in all roles and settings.
The Code of Ethics provisions outline the nurse's duty to the patient, the healthcare team, the profession, and society. The Code's fundamental principles include advocacy,...
Ethical Dilemmas I01:17

Ethical Dilemmas I

Ethical dilemmas in nursing are of utmost importance, as they often arise from the tension between adhering to core ethical principles and the practical realities of healthcare delivery. These dilemmas require nurses to navigate complex situations where competing ethical considerations pull them in different directions.
Let us explore some examples to understand the potentially complex moral decisions nurses face.
Take the case of caring for minors, particularly in areas related to reproductive...
Ethics in Research01:56

Ethics in Research

Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.

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Related Experiment Video

Updated: Jul 9, 2026

Using Visual and Narrative Methods to Achieve Fair Process in Clinical Care
14:32

Using Visual and Narrative Methods to Achieve Fair Process in Clinical Care

Published on: February 16, 2011

Ethics at phase 0: clarifying the issues.

Jonathan Kimmelman1

  • 1Biomedical Ethics Unit at McGill University, Canada.

The Journal of Law, Medicine & Ethics : a Journal of the American Society of Law, Medicine & Ethics
|December 14, 2007
PubMed
Summary
This summary is machine-generated.

Microdosing in drug development, particularly in oncology, faces ethical scrutiny regarding risk-benefit balance and commercial interests. However, this article argues microdosing can ethically enhance early-phase clinical trials by improving evidentiary justification.

Related Experiment Videos

Last Updated: Jul 9, 2026

Using Visual and Narrative Methods to Achieve Fair Process in Clinical Care
14:32

Using Visual and Narrative Methods to Achieve Fair Process in Clinical Care

Published on: February 16, 2011

Area of Science:

  • Pharmacology
  • Clinical Trials
  • Bioethics

Background:

  • Regulatory agencies like the FDA and EMEA encourage microdose testing before Phase I trials.
  • Microdosing is predicted to become more common in drug development.
  • Ethical criticisms question the validity and risk-benefit balance of microdose trials, alongside concerns about commercial motivations.

Purpose of the Study:

  • To explore the ethical concerns surrounding microdose trials in the oncology setting.
  • To evaluate the consistency of microdosing with current Phase I research practices.
  • To determine if microdosing can strengthen the ethical foundation of Phase I trials.

Main Methods:

  • Review of ethical criticisms regarding microdose exploratory testing.
  • Analysis of microdosing within the context of oncology Phase I trials.
  • Examination of the evidentiary justification provided by microdosing.

Main Results:

  • Microdosing in oncology trials is not inherently inconsistent with existing Phase I practices.
  • Ethical concerns include questions about trial validity, subject risk-benefit ratios, and commercial interests.
  • Microdosing can offer better evidentiary justification for Phase I studies.

Conclusions:

  • Microdosing presents a potentially stronger ethical basis for Phase I trials.
  • The methodology can be ethically integrated into early-phase drug development, especially in oncology.
  • Addressing ethical criticisms is crucial for the routine adoption of microdosing.