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Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors
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VIP inhibits human HepG2 cell proliferation in vitro

Afaf Absood1, Bin Hu, Nermine Bassily

  • 1Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Regulatory Peptides
|December 14, 2007
PubMed
Summary

Vasoactive intestinal peptide (VIP) inhibits hepatocellular carcinoma (HCC) cell growth by reducing signal transducers and activators of transcription-3 (STAT-3) and cyclic AMP (cAMP) levels. This suggests VIP as a potential therapeutic agent for HCC.

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