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Related Experiment Video

Updated: Jul 9, 2026

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Published on: June 29, 2018

Genetic contributions to long-range temporal correlations in ongoing oscillations.

Klaus Linkenkaer-Hansen¹, Dirk J A Smit, Andre Barkil

¹Department of Experimental Neurophysiology, Institute for Neuroscience, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands. klaus.linkenkaer@cncr.vu.nl

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

|December 14, 2007

Summary

Genetic factors significantly influence the long-range temporal correlations (LRTC) in human brain oscillations. These brain signal patterns are highly heritable and distinct from oscillation power, suggesting unique biological mechanisms.

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Generation of Local CA1 γ Oscillations by Tetanic Stimulation

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Published on: August 14, 2015

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Last Updated: Jul 9, 2026

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Published on: June 29, 2018

Generation of Local CA1 γ Oscillations by Tetanic Stimulation

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Published on: August 14, 2015

Area of Science:

Neuroscience
Genetics
Biophysics

Background:

Ongoing brain oscillations exhibit long-range temporal correlations (LRTC) in their amplitude fluctuations.
Abnormal LRTC are linked to brain pathologies, but their genetic basis was unknown.

Purpose of the Study:

To investigate the heritability of LRTC in ongoing electroencephalographic (EEG) oscillations.
To determine if genetic factors influence the temporal correlation structure of brain activity.

Main Methods:

Recorded resting-state EEG from 390 monozygotic and dizygotic twins.
Analyzed temporal structure of alpha and beta oscillations using detrended fluctuation analysis (DFA).

Main Results:

LRTC strength showed higher correlation in monozygotic than dizygotic twins.
Genetic factors accounted for up to 60% of the variance in DFA.
LRTC were independent of EEG power.

Conclusions:

The temporal structure of EEG oscillations is highly heritable.
LRTC and oscillation power are governed by distinct mechanisms.
DFA is a valuable tool complementing spectral analysis for brain oscillation research.