Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Rational Dosage Regimen: Maintenance Dose and Loading Dose

Rational Dosage Regimen: Maintenance Dose and Loading Dose

A rational dosage regimen considers a drug's pharmacokinetics, including its absorption, distribution, metabolism, and elimination from the body. By understanding these factors, the appropriate dosage can be determined, and the dosing schedule can be designed to achieve and maintain the desired therapeutic effect while minimizing adverse effects.
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady state,...

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...

Kidney Transplant III: Nursing Management

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...

Dosage Regimens: Designs and Approaches

Dosage Regimens: Designs and Approaches

Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Evaluating Barriers to Kidney Transplantation in the United States.

Journal of the American Society of Nephrology : JASN·2026

Same author

Elevations in Donor-Derived Cell-Free DNA and Allograft Outcomes in Kidney Transplantation.

Journal of the American Society of Nephrology : JASN·2026

Same author

Incorporating Model for End-stage Liver Disease Trajectories into Liver Allocation.

Transplantation·2026

Same author

Pancreas Transplantation for Recipients with Type 2 Diabetes Mellitus: Results of an International Survey.

Transplantation direct·2026

Same author

Portal-Venous Hypothermic Oxygenated Perfusion for Liver Transplant: A Randomized Clinical Trial.

JAMA surgery·2026

Same author

Assessment of colorectal cancer recurrence risk following solid organ transplantation.

Journal of gastrointestinal oncology·2026

Search research articles

Related Experiment Video

Updated: Jul 9, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Published on: November 8, 2015

Novel methods for tracking long-term maintenance immunosuppression regimens.

Paula M Buchanan¹, Mark A Schnitzler, Daniel C Brennan

¹Center for Outcomes Research, St. Louis University School of Medicine, St. Louis, Missouri, USA.

Clinical Journal of the American Society of Nephrology : CJASN

|December 14, 2007

Summary

Accurate kidney transplant immunosuppression data can be obtained from electronic medical records, Organ Procurement and Transplantation Network (OPTN) surveys, and Medicare pharmacy claims. These sources show excellent agreement for key medications one year post-transplant.

More Related Videos

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Related Experiment Videos

Last Updated: Jul 9, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Published on: November 8, 2015

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Area of Science:

Nephrology
Transplantation Research
Health Informatics

Background:

Accurate assessment of immunosuppressive medication use is crucial for observational studies in transplantation.
This study evaluated three data sources for maintenance immunosuppression information.

Purpose of the Study:

To assess the accuracy of electronic medical records, OPTN survey data, and Medicare pharmacy claims for tracking immunosuppression.
To determine the concordance of these data sources at different time points post-kidney transplantation.

Main Methods:

Compared immunosuppression data from linked electronic medical records, OPTN surveys, and Medicare pharmacy claims for kidney transplant recipients.
Utilized pair-wise concordance (kappa) and percentage agreement statistics.
Analyzed data at discharge, 6 months, and 1 year post-transplant.

Main Results:

Agreement between data sources for non-steroid immunosuppression improved over time.
Excellent 1-year concordance (kappa 0.79-1.00) for calcineurin inhibitors and mycophenolate mofetil.
Very good 1-year concordance (kappa 0.73-0.85) for azathioprine, with high percentage agreement (87.5-100%).

Conclusions:

Electronic medical records, OPTN surveys, and pharmacy claims are accurate sources for describing non-steroid immunosuppression post-kidney transplant.
Using alternative data measures for immunosuppression exposure is appropriate and increasingly important.
Supports the validity of these data sources for transplantation research.