Related Experiment Video
Updated: Jul 9, 2026

Serial Enrichment of Spermatogonial Stem and Progenitor Cells (SSCs) in Culture for Derivation of Long-term Adult Mouse SSC Lines
Published on: February 25, 2013
[Update of the researches on the niche for spermatogonial stem cells]
1PLA Research Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Command, PLA, Nanjing, Jiangsu 210002, China.
Abstract:
Spermatogonial stem cells are a population of immortal cells, capable of self-renewal and multi-directional differentiation. The theory of the "stem cell niche" was originally proposed for the hematopoietic system, and niches also exist in testicular tissues. The niche for spermatogonial stem cells is a semi-isolation system, characteristic of specific number regulation and changing with the age. The self-renewal of spermatogonial stem cells is regulated by two endogenous factors, nanos2 and Plzf, as well as by the niche cell-excreted factor, glial-derived neurotrophic factor (GDNF).
Related Concept Videos
Spermatogenesis
Spermatogenesis
The process of spermatogenesis can be divided into mitosis, meiosis, and spermiogenesis. During mitosis, the spermatogonia or stem cells divide to produce two identical daughter cells, type A and B spermatogonia. Type-A...
Stem Cell Niche
Multipotency and Niche of Bulge Stem Cell
Maintenance of the ES Cell State
Zygotic Development And Stem Cell Formation

