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Updated: Jul 9, 2026
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Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
Published on: October 12, 2012
Utilizing enoxaparin in the management of STEMI
Andrea Rubboli1, Alessandro Capecchi, Giuseppe Di Pasquale
1Division of Cardiology, Maggiore Hospital, Bologna, Italy. andrearubboli@libero.it
Vascular Health and Risk Management
|December 15, 2007
Summary
Enoxaparin demonstrates superior efficacy in reducing reinfarction for ST-elevation myocardial infarction (STEMI) patients undergoing thrombolysis compared to unfractionated heparin (UFH). Its subcutaneous administration offers easier use and allows for early patient mobilization.
Area of Science:
- Cardiology
- Pharmacology
Background:
- ST-elevation acute myocardial infarction (STEMI) treatment involves thrombolysis.
- The role of enoxaparin versus unfractionated heparin (UFH) in STEMI is under investigation.
Purpose of the Study:
- To evaluate the efficacy and safety of enoxaparin compared to UFH in STEMI patients receiving thrombolysis.
Main Methods:
- Review of 8 open-label studies (10,000 patients) and one large double-blind randomized trial (20,000 patients).
- Comparison of enoxaparin with placebo or UFH regarding reinfarction, artery patency, and bleeding events.
Main Results:
- Enoxaparin showed superiority in reducing reinfarction and improving infarct-related artery patency.
- Bleeding rates were comparable to UFH, with a noted increase in intracranial bleeding in elderly patients with pre-hospital administration in one study.
- A large mega-trial confirmed enoxaparin's superior efficacy and comparable safety to UFH for STEMI treatment.
Conclusions:
- Enoxaparin is a preferred alternative to UFH for STEMI patients receiving thrombolysis.
- Subcutaneous enoxaparin offers advantages including ease of use, no need for lab monitoring, extended treatment, and early patient mobilization.
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