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Published on: April 18, 2019

[Imipenem resistance in Gram-negative rods and its consumption between 1999 and 2005]

Eugenia Gospodarek1, Krzysztof Gierlotka, Aleksander Deptuła

  • 1Katedra i Zakład Mikrobiologii, Collegium Medicum im. L. Rydygiera w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu.

Medycyna Doswiadczalna I Mikrobiologia
|December 15, 2007
PubMed

Insights

Multidrug-resistant Gram-negative rods, particularly Pseudomonas aeruginosa, are rising in hospitals. Imipenem resistance correlates with increased imipenem consumption, highlighting a critical public health concern.

Area of Science:

  • Clinical microbiology
  • Infectious diseases
  • Antimicrobial resistance

Context:

  • Increasing isolation of multidrug-resistant Gram-negative rods from clinical settings.
  • Focus on hospitalized patients, especially in intensive care and rehabilitation units.
  • Need to understand trends in antibiotic resistance and consumption.

Purpose:

  • Evaluate the prevalence of imipenem-resistant Gram-negative rods.
  • Analyze imipenem consumption patterns between 1999 and 2005.
  • Correlate resistance trends with antibiotic usage.

Summary:

  • 2.0% of 109,614 isolated microorganisms were imipenem-resistant Gram-negative rods.
  • Pseudomonas aeruginosa was the predominant resistant strain (88.9%).
  • Imipenem consumption showed a direct correlation with the rise in imipenem-resistant Gram-negative rods.

Impact:

  • Highlights the link between imipenem use and resistance.
  • Informs antimicrobial stewardship strategies.
  • Underscores the threat of Gram-negative bacterial infections in healthcare settings.

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