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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles
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Stable stealth function for hollow polyelectrolyte microcapsules through a poly(ethylene glycol) grafted

Uta Wattendorf1, Oliver Kreft, Marcus Textor

  • 1Institute for Pharmaceutical Sciences, ETH Zurich, 8093 Zurich, Switzerland, Max-Planck Institute of Colloids and Interfaces, Research Campus Golm, 14424 Potsdam, Germany.

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To improve drug delivery systems, researchers modified polyelectrolyte microcapsules with poly(ethylene glycol)-grafted poly-L-lysine (PLL-g-PEG). This coating effectively prevented clearance by the mononuclear phagocytic system (MPS).

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Hollow polyelectrolyte microcapsules are promising for biomedical applications, including drug delivery.
  • Surface modification is crucial to prevent rapid clearance by the mononuclear phagocytic system (MPS).

Purpose of the Study:

  • To investigate the effect of poly(ethylene glycol) (PEG)-grafted polyelectrolyte coatings on the MPS recognition of layer-by-layer assembled microcapsules.
  • To evaluate the potential of these modified microcapsules as drug delivery systems that evade MPS clearance.

Main Methods:

  • Fabrication of hollow polyelectrolyte microcapsules using layer-by-layer assembly of polystyrene sulfonate (PSS) and polyallylamine hydrochloride (PAH).
  • Coating microcapsules with adlayers of poly(ethylene glycol)-grafted poly-L-lysine (PLL-g-PEG) or poly-L-glutamic acid (PGA-g-PEG).
  • Assessment of MPS recognition using primary cell cultures of human monocyte-derived dendritic cells and macrophages.

Main Results:

  • PLL-g-PEG coatings effectively blocked phagocytosis of the microcapsules by MPS cells.
  • PGA-g-PEG coatings showed limited effect on cellular recognition, potentially due to insufficient PEG density.
  • PLL-g-PEG coatings demonstrated stability for at least 3 weeks.
  • The PAH/PSS microcapsules did not negatively impact phagocyte viability.

Conclusions:

  • Layer-by-layer assembled polyelectrolyte microcapsules coated with PLL-g-PEG offer a promising strategy for developing drug delivery systems.
  • These modified microcapsules can effectively escape rapid clearance by the mononuclear phagocytic system.
  • This approach holds potential for enhancing the efficacy and longevity of drug delivery systems.