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Related Experiment Videos

Changing antibiotic sensitivity patterns in shigellosis.

S P Lamabadusuriya1, I V Devasiri, U K Jayantha

  • 1Department of Paediatrics, Faculty of Medicine Galle.

The Ceylon Medical Journal
|December 1, 1991
PubMed
Summary

This study investigated bacterial causes of dysentery in Galle, finding Shigella dysenteriae type 1 and Shigella flexneri in 31 patients. Antibiotic resistance patterns varied between the two Shigella types, differing from Colombo findings.

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Paediatrics

Background:

  • Bacillary dysentery is a significant public health concern, particularly in paediatric populations.
  • Understanding the aetiology and antibiotic susceptibility of causative agents is crucial for effective treatment and control.

Purpose of the Study:

  • To identify the bacterial pathogens responsible for suspected bacillary dysentery in paediatric patients.
  • To determine the antibiotic sensitivity patterns of isolated Shigella species.
  • To compare findings with regional data from Colombo.

Main Methods:

  • Stool cultures were performed on 154 paediatric patients presenting with suspected bacillary dysentery.
  • Isolation and identification of Shigella species were conducted.

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  • Antibiotic sensitivity testing was performed on all positive isolates.

    • Main Results:

    • Thirty-one patients (20.1%) had positive stool cultures.
    • Shigella dysenteriae type 1 was identified in 23 patients, and Shigella flexneri in 8 patients.
    • Shigella dysenteriae type 1 exhibited resistance to nalidixic acid, while Shigella flexneri remained sensitive; both showed uniform sensitivity patterns within their respective groups.
    • Observed antibiotic sensitivity patterns differed from those reported in Colombo during the same period.
    • Complications were noted in some patients infected with Shigella flexneri.

    Conclusions:

    • Shigella species, particularly Shigella dysenteriae type 1 and Shigella flexneri, are key causative agents of bacillary dysentery in this paediatric cohort.
    • Distinct antibiotic resistance profiles for Shigella dysenteriae type 1 and Shigella flexneri necessitate tailored treatment strategies.
    • Regional variations in antibiotic sensitivity underscore the importance of local surveillance for guiding antimicrobial therapy in dysentery.