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Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy

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Acute encephalitis with refractory, repetitive partial seizures.

Ching-Shan Shyu¹, Hsiu-Fen Lee, Ching-Shiang Chi

¹Department of Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.

Brain & Development

|December 15, 2007

Summary

Acute encephalitis with refractory, repetitive partial seizures (AERRPS) is a newly identified epileptic syndrome. This study details its clinical features, poor prognosis, and refractoriness to treatment in Taiwanese children, highlighting the need for further etiological research.

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Area of Science:

Pediatric Neurology
Epileptology
Infectious Diseases

Background:

Acute encephalitis with refractory, repetitive partial seizures (AERRPS) is a recently described epileptic syndrome.
Limited information exists on AERRPS clinical manifestations, neuroimaging, and outcomes in Taiwan.

Purpose of the Study:

To report the clinical features, neuroimaging findings, and prognosis of AERRPS in Taiwanese children.
To analyze the clinical course, virology, medication responses, EEG, and neuroimaging in AERRPS patients.

Main Methods:

Retrospective analysis of 14 children diagnosed with AERRPS between 2000 and 2006.
Inclusion criteria based on established diagnostic criteria for AERRPS.
Data collected included clinical course, virology, medications, EEG, neuroimaging, and prognosis.

Main Results:

Fourteen children (1.2-15.5 years) presented with fever, URI, or GI symptoms preceding seizures.
Seizures were refractory to antiepileptic drugs (AEDs); patients experienced prolonged fever, AED hypersensitivity, and liver dysfunction.
EEG showed epileptiform discharges; MRI revealed initial normal scans progressing to focal abnormalities and later generalized brain atrophy in over 50% of cases.

Conclusions:

Clinical features support AERRPS as a distinct epileptic syndrome.
The syndrome has a poor prognosis with psychomotor retardation and persistent refractory seizures.
Further research into the etiology of AERRPS is crucial for developing effective treatments.