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High-sensitivity C-reactive protein level is a significant risk factor for silent cerebral infarction in patients on

Futoshi Anan1, Tsuyoshi Shimomura, Tadayuki Kaku

  • 1Department of Cardiology, Oita Red Cross Hospital, Oita 870-0033, Japan. anan-f@med.oita-u.ac.jp

Metabolism: Clinical and Experimental
|December 15, 2007
PubMed

Insights

High-sensitivity C-reactive protein (HSCRP) levels are significantly associated with silent cerebral infarctions (SCIs) in hemodialysis patients. This finding highlights HSCRP as a key indicator for SCI risk in chronic kidney disease.

Area of Science:

  • Nephrology
  • Neurology
  • Cardiovascular Science

Background:

  • Silent cerebral infarctions (SCIs) are linked to high mortality in hemodialysis (HD) patients.
  • High-sensitivity C-reactive protein (HSCRP) levels increase with renal dysfunction, indicating inflammation and atherosclerosis.

Purpose of the Study:

  • To investigate the correlation between elevated HSCRP levels and the occurrence of SCIs in patients undergoing HD.
  • To identify risk factors associated with SCIs in this patient population.

Main Methods:

  • Brain MRI was used to categorize 54 HD patients into with-SCI (n=30) and without-SCI (n=24) groups.
  • Comparisons included demographics, metabolic profiles, HSCRP levels, and smoking habits.

Main Results:

  • Higher HSCRP levels were observed in the with-SCI group (P < .0001).
  • The with-SCI group had a higher proportion of smokers (P < .05) and lower high-density lipoprotein cholesterol, with higher uric acid levels (P < .05 and P < .0001, respectively).
  • Multivariate analysis confirmed HSCRP as a significant predictor of SCI (OR, 1.61; 95% CI, 1.17-2.85; P < .001).

Conclusions:

  • Patients with chronic renal failure on HD have a higher prevalence of SCIs.
  • Elevated HSCRP levels are significantly associated with the presence of SCIs in HD patients, suggesting its role as a potential biomarker.

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