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Cortical folding patterns and predicting cytoarchitecture.

Bruce Fischl1, Niranjini Rajendran, Evelina Busa

  • 1Department of Radiology, Harvard Medical School, Charlestown, MA 02129, USA. fischl@nmr.mgh.harvard.edu

Cerebral Cortex (New York, N.Y. : 1991)
|December 15, 2007
PubMed
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Cortical folding patterns accurately predict Brodmann areas (BAs) locations. Higher-order cortical areas show more variability than primary ones, suggesting linked development of folds and brain regions.

Area of Science:

  • Neuroscience
  • Neuroanatomy
  • Computational Neuroscience

Background:

  • The human cerebral cortex is organized into structural areas known as Brodmann areas (BAs).
  • Cortical folding patterns are commonly used to estimate BA locations, but variability is poorly understood.
  • Key questions include the positional variability of BAs relative to folds and potential hierarchical influences.

Purpose of the Study:

  • To investigate the variability in the position of Brodmann areas (BAs) concerning cortical folds.
  • To determine if some BAs exhibit greater positional variability than others.
  • To explore the relationship between BA variability and its hierarchical level within the cortex.

Main Methods:

  • Utilized whole-brain histology from 10 postmortem human brains.

Related Experiment Videos

  • Employed surface-based analysis to assess the predictive power of cortical folds for BA locations.
  • Quantified the variability of Brodmann area positions relative to anatomical landmarks.

    • Main Results:

    • Cortical folding patterns are more effective predictors of Brodmann area locations than previously assumed.
    • Higher-order cortical areas demonstrate significantly greater positional variability compared to primary and secondary areas.
    • Found a notable correlation between the hierarchical level of a BA and its positional variability.

    Conclusions:

    • Cortical folds are reliable indicators for locating Brodmann areas.
    • The observed variability patterns suggest a shared developmental mechanism for cortical folding and cytoarchitectonic fields.
    • Findings underscore the importance of cortical gyrification in brain organization and functional localization.