Related Experiment Video

Updated: Jul 9, 2026

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

Effects of percutaneous coronary intervention on peripheral venous blood circulating endothelial cells and plasma

Christopher J Boos1, Balu Balakrishnan, Shahirose Jessani

  • 1Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham B18 7QH, UK.

Chest
|December 15, 2007
PubMed

Insights

Percutaneous coronary intervention (PCI) significantly increases markers of endothelial damage, including circulating endothelial cells (CECs), von Willebrand factor (vWF), and soluble E-selectin (sEsel). Diagnostic coronary angiography (CA) did not show these effects, indicating PCI causes endothelial dysfunction.

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Endothelial Biology

Background:

  • Endothelial damage/dysfunction is linked to coronary artery disease.
  • The impact of percutaneous coronary intervention (PCI) on endothelial damage markers is not fully understood.
  • Key markers include circulating endothelial cells (CECs), von Willebrand factor (vWF), and soluble E-selectin (sEsel).

Purpose of the Study:

  • To evaluate the effects of diagnostic coronary angiography (CA) and PCI on CECs, vWF, and sEsel levels.
  • To compare baseline levels of these markers in patients and healthy controls.

Main Methods:

  • Blood samples were collected before and after CA (n=15).
  • Blood samples were collected before, 15 minutes after, and 24 hours after PCI (n=38).
  • Levels of CECs, vWF, and sEsel were measured in patients undergoing CA, PCI, and in healthy controls.

Main Results:

  • No significant differences in baseline endothelial marker levels were found between healthy controls, CA, and PCI groups.
  • CA did not significantly alter vWF or CEC levels.
  • PCI led to significant increases in CECs, vWF, and sEsel at 15 minutes and 24 hours post-procedure compared to pre-PCI levels.

Conclusions:

  • Elective PCI causes significant increases in circulating endothelial cells, von Willebrand factor, and soluble E-selectin.
  • Diagnostic coronary angiography does not appear to induce similar changes in these endothelial markers.
  • The observed increases suggest endothelial damage or dysfunction following PCI.
Abstract

More Related Videos

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Related Concept Videos

Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
Assessment of the Cardiovascular System III: Palpation01:27

Assessment of the Cardiovascular System III: Palpation

Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above the...
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...