[Antidepressive treatments. Predictive factors of tolerability]

Conducting an antidepressant treatment supposes the analysis of various parameters concerning patients, depressive illness and psychotropic drugs. The first determinant of prescription is the expected antidepressant effect. But regarding the role of compliance in the efficacy of treatment, probable tolerability also plays a role. It remains difficult to predict tolerability. A questionnaire was designed to assess the relevance of various predictive factors taken into account in the prognosis of tolerability: global tolerability, patient's psychopathological structure, clinical aspects of depression and characteristics of the particular antidepressant being used.