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Related Concept Videos

Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
Increased Intracranial Pressure ll: Pathophysiology01:29

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Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...
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Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...
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Related Experiment Video

Updated: Jul 9, 2026

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
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[Thunderclap headache caused by cerebellar infarction].

G Gossrau1, C Dannenberg, H Reichmann

  • 1Universitätsschmerzzentrum, Universitätsklinikum der TU Dresden, Fetscherstr. 74, 01309, Dresden, Deutschland. Gudrun.Gossrau@neuro.med.tu-dresden.de

Schmerz (Berlin, Germany)
|December 15, 2007
PubMed
Summary

Thunderclap headache can signal serious neurovascular conditions. A cerebellar infarction was diagnosed via MRI in a patient with normal initial tests, highlighting the need for advanced imaging.

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Last Updated: Jul 9, 2026

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Area of Science:

  • Neurology
  • Neuroimaging
  • Vascular Neurology

Background:

  • Thunderclap headache is a critical symptom demanding urgent evaluation for life-threatening causes.
  • Neurovascular disorders, such as subarachnoid hemorrhage, are common considerations.

Observation:

  • A 44-year-old male presented with isolated thunderclap headache.
  • Neurological examination, routine blood tests, CT scan, and cerebrospinal fluid analysis were unremarkable.

Findings:

  • Cerebral MRI revealed a right cerebellar infarction as the underlying cause.
  • This diagnosis was made despite the absence of other neurological deficits or abnormal initial investigations.

Implications:

  • Cerebellar infarction should be included in the differential diagnosis of thunderclap headache.
  • Magnetic resonance imaging is crucial for diagnosing symptomatic thunderclap headache when initial tests are normal.