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Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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Related Experiment Video

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Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
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Published on: August 14, 2019

Flavonoids as RTK inhibitors and potential anticancer agents.

Florence Teillet1, Ahcene Boumendjel, Jean Boutonnat

  • 1Laboratoire de Dynamique Cellulaire, EPHE, Laboratoire TIMC-IMAG, UMR-CNRS 5525, Université Joseph Fourier, Pavillon Taillefer, 38706 La Tronche Cedex, France.

Medicinal Research Reviews
|December 15, 2007
PubMed
Summary

Flavonoids, natural compounds, inhibit tyrosine kinase receptors (RTKs) by binding to their ATP-binding site. This review explores their antiproliferative potential and clinical applications as RTK inhibitors.

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Last Updated: Jul 9, 2026

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
09:50

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Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
12:00

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro

Published on: July 5, 2017

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • Tyrosine kinase receptors (RTKs) are critical regulators of cell division.
  • Over 50 RTKs are known, grouped into distinct subfamilies.
  • Inhibiting RTK activity is a key area of research for therapeutic intervention.

Purpose of the Study:

  • To review recent findings on natural and synthetic flavonoid derivatives as RTK inhibitors.
  • To discuss the mechanisms of action, therapeutic utility, and clinical potential of these compounds.
  • To highlight flavonoids as promising small molecules targeting RTKs.

Main Methods:

  • Literature review of studies on flavonoid RTK inhibition.
  • Analysis of mechanistic data regarding flavonoid-ATP-binding site interactions.
  • Evaluation of reported antiproliferative activities and therapeutic potential.

Main Results:

  • Flavonoids act as RTK inhibitors by binding to the ATP-binding site.
  • The chromenone moiety of flavonoids mimics ATP's adenine, explaining their kinase inhibitory action.
  • Both natural and synthetic flavonoid derivatives show significant RTK inhibitory activity.

Conclusions:

  • Flavonoids are effective inhibitors of tyrosine kinase receptors.
  • Their ability to target RTKs suggests potential as antiproliferative agents.
  • Further research into their therapeutic and clinical applications is warranted.