[When to suspect immunologic deficiency?]

Symptoms and signs that point to immunodeficiency are numerous and various. Recurrent history, unusual pathogens or severe course of infections should alert any physician to potential immunodeficiency state. If infections are the hallmark of immunodeficiency, other manifestations such as autoimmune diseases or particular malignancies can be a presenting feature of immunodeficiency. If many primary or secondary immunodeficiencies are well defined, it is important for the general practitioners to know that a large number of underlying conditions can lead to immunodeficiency states.