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Updated: Jul 9, 2026

Isolation of Leukocytes from the Human Maternal-fetal Interface

Isolation of Leukocytes from the Human Maternal-fetal Interface

Published on: May 21, 2015

Leukaemia and pregnancy.

M F Fey¹, D Surbek

¹Department of Medical Oncology, Inselspital and University, Bern, Switzerland.

Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progres Dans Les Recherches Sur Le Cancer

|December 18, 2007

Summary

This summary is machine-generated.

Managing leukaemia during pregnancy requires an interdisciplinary approach. Treatment timing is crucial, with acute leukaemia therapy typically starting in the second trimester, while chronic leukaemias may be managed post-delivery.

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Modeling Chemotherapy Resistant Leukemia In Vitro

Modeling Chemotherapy Resistant Leukemia In Vitro

Published on: February 9, 2016

Area of Science:

Oncology
Maternal-Fetal Medicine
Hematology

Background:

Leukaemia diagnosis during pregnancy presents complex management challenges for both mother and fetus.
Requires careful consideration of oncological treatment efficacy and obstetric outcomes.

Purpose of the Study:

To outline an interdisciplinary management strategy for pregnant women diagnosed with leukaemia.
To detail treatment protocols and safety considerations for various leukaemia types during pregnancy.

Main Methods:

Review of current treatment guidelines and literature for leukaemia in pregnancy.
Emphasis on interdisciplinary collaboration between oncologists, hematologists, and obstetricians.
Fetal monitoring and assessment of treatment toxicities.

Main Results:

Prognosis for pregnant women with acute leukaemia is comparable to non-pregnant patients when treated appropriately, ideally starting in the second trimester.
Chemotherapy in the second trimester poses acceptable fetal toxicity risks, including potential prematurity or developmental delays, but no clear long-term sequelae.
Chronic leukaemias and myelodysplastic syndromes (MDS) may allow for delayed treatment until after delivery; imatinib mesylate in chronic myeloid leukaemia (CML) is safe from the second trimester.

Conclusions:

An interdisciplinary approach is essential for managing leukaemia in pregnancy, involving oncological work-up and close pregnancy monitoring.
Treatment timing is critical, balancing maternal oncological needs with fetal safety, particularly avoiding first-trimester treatment for acute leukaemias.
Comprehensive obstetric care and monitoring throughout pregnancy are vital for optimal maternal and fetal outcomes.