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Related Experiment Video

Updated: Jul 9, 2026

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
10:04

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

Published on: May 1, 2015

[Amylase-producing multiple myeloma: a case report].

Minako Mori1, Hayato Maruoka, Yuya Nagai

  • 1Department of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|December 18, 2007
PubMed
Summary

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This study reports a rare case of amylase-producing multiple myeloma in an 80-year-old man. The condition was confirmed through immunocytochemistry, cell culture, and gene expression analysis.

Area of Science:

  • Hematology
  • Oncology
  • Biochemistry

Background:

  • Multiple myeloma is a plasma cell malignancy.
  • Elevated serum amylase can indicate various conditions, but pancreatic involvement is common.
  • Amylase-producing multiple myeloma is an exceedingly rare subtype.

Observation:

  • An 80-year-old male presented with acute thrombocytopenia and renal failure, diagnosed as Bence Jones (lambda)-type multiple myeloma with sepsis.
  • Elevated serum amylase (S-amylase) activity was noted on admission.
  • Myeloma cells in pleural effusion demonstrated cytoplasmic amylase positivity and secreted S-amylase in vitro.

Findings:

  • The patient's myeloma cells expressed S-amylase, confirmed by immunocytochemistry, cell culture supernatant analysis, and RT-PCR.

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Published on: January 7, 2019

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Last Updated: Jul 9, 2026

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  • This confirmed a diagnosis of amylase-producing multiple myeloma.
  • The patient ultimately succumbed to renal insufficiency and disseminated intravascular coagulation.

    • Implications:

    • This case highlights an unusual paraneoplastic manifestation of multiple myeloma.
    • It underscores the importance of considering rare enzyme production by myeloma cells in complex clinical presentations.
    • Further research into the mechanisms and clinical significance of amylase production in myeloma is warranted.